AustralieFrV1, Main, Exploration, bibRecord, 008E24

Common sequence variants on 20qll.22 confer melanoma susceptibility

Identifieur interne : 008E24 ( Main/Exploration ); précédent : 008E23; suivant : 008E25

Common sequence variants on 20qll.22 confer melanoma susceptibility

Auteurs : Kevin M. Brown [États-Unis] ; Stuart Macgregor [Australie] ; Grant W. Montgomery [Australie] ; David W. Craig [États-Unis] ; ZHEN ZHEN ZHAO [Australie] ; Kelly Iyadurai [États-Unis] ; Anjali K. Henders [Australie] ; Nils Homer [États-Unis] ; Megan J. Campbell [Australie] ; Mitchell Stark [Australie] ; Shane Thomas [Australie] ; Helen Schmid [Australie] ; Elizabeth A. Holland [Australie] ; Elizabeth M. Gillanders [États-Unis] ; David L. Duffy [Australie] ; Judith A. Maskiell [Australie] ; Jodie Jetann [Australie] ; Megan Ferguson [Australie] ; Dietrich A. Stephan [États-Unis] ; Anne E. Cust [Australie] ; David Whiteman [Australie] ; Adele Green [Australie] ; Hakan Olsson [Suède] ; Susana Puig [Espagne] ; Paola Ghiorzo [Italie] ; Johan Hansson [Suède] ; Florence Demenais [France] ; Alisa M. Goldstein [États-Unis] ; Nelleke A. Gruis [Pays-Bas] ; David E. Elder [États-Unis] ; Julia Newton Bishop [Royaume-Uni] ; Richard F. Kefford [Australie] ; Graham G. Giles [Australie] ; Bruce K. Armstrong [Australie] ; Joanne F. Aitken [Australie] ; John L. Hopper [Australie] ; Nicholas G. Martin [Australie] ; Jeffrey M. Trent [États-Unis] ; Graham J. Mann [Australie] ; Nicholas K. Hayward [Australie]

Source :

Nature genetics [ 1061-4036 ] ; 2008.

RBID : Pascal:08-0364144

Descripteurs français

Pascal (Inist)
- Variant, Mélanome malin, Association génétique.

English descriptors

KwdEn :
- Malignant melanoma, Variant.

Abstract

We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10 ¹⁵). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755512

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Common sequence variants on 20qll.22 confer melanoma susceptibility</title>
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<author><name sortKey="Homer, Nils" sort="Homer, Nils" uniqKey="Homer N" first="Nils" last="Homer">Nils Homer</name>
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<author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name>
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<country>Espagne</country>
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<author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
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<country>France</country>
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</affiliation>
</author>
<author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name>
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<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
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</author>
<author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name>
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<s3>NLD</s3>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2333 AL Leiden</wicri:noRegion>
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</author>
<author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name>
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</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia, Pennsylvania 19104</wicri:noRegion>
</affiliation>
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<author><name sortKey="Newton Bishop, Julia" sort="Newton Bishop, Julia" uniqKey="Newton Bishop J" first="Julia" last="Newton Bishop">Julia Newton Bishop</name>
<affiliation wicri:level="4"><inist:fA14 i1="17"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds</s1>
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<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Leeds</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Yorkshire-et-Humber</region>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Kefford, Richard F" sort="Kefford, Richard F" uniqKey="Kefford R" first="Richard F." last="Kefford">Richard F. Kefford</name>
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<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
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<country>Australie</country>
<wicri:noRegion>Carlton, Victoria 3053</wicri:noRegion>
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<author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name>
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<s2>Sydney, New South Wales 2006</s2>
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<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
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<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name>
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<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
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<sZ>16 aut.</sZ>
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<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
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<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
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<author><name sortKey="Trent, Jeffrey M" sort="Trent, Jeffrey M" uniqKey="Trent J" first="Jeffrey M." last="Trent">Jeffrey M. Trent</name>
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<author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Westmead Institute of Cancer Research and Sydney Melanoma Unit, University of Sydney at Westmead Millennium Institute</s1>
<s2>Westmead, New South Wales 2145</s2>
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<country>Australie</country>
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</author>
<author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Population Studies and Genetics Division, Queensland Institute of Medical Research</s1>
<s2>Brisbane, Queensland 4029</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
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</inist:fA14>
<country>Australie</country>
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</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Malignant melanoma</term>
<term>Variant</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Variant</term>
<term>Mélanome malin</term>
<term>Association génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10 <sup>15</sup>
). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.</div>
</front>
</TEI>
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<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
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<li>Suède</li>
<li>États-Unis</li>
</country>
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<li>Catalogne</li>
<li>Nouvelle-Galles du Sud</li>
<li>Victoria (État)</li>
<li>Yorkshire-et-Humber</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Leeds</li>
<li>Melbourne</li>
<li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Barcelone</li>
<li>Université de Leeds</li>
<li>Université de Melbourne</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name>
</noRegion>
<name sortKey="Craig, David W" sort="Craig, David W" uniqKey="Craig D" first="David W." last="Craig">David W. Craig</name>
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<name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name>
<name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name>
<name sortKey="Homer, Nils" sort="Homer, Nils" uniqKey="Homer N" first="Nils" last="Homer">Nils Homer</name>
<name sortKey="Iyadurai, Kelly" sort="Iyadurai, Kelly" uniqKey="Iyadurai K" first="Kelly" last="Iyadurai">Kelly Iyadurai</name>
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<name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name>
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<name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name>
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<name sortKey="Maskiell, Judith A" sort="Maskiell, Judith A" uniqKey="Maskiell J" first="Judith A." last="Maskiell">Judith A. Maskiell</name>
<name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
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<name sortKey="Stark, Mitchell" sort="Stark, Mitchell" uniqKey="Stark M" first="Mitchell" last="Stark">Mitchell Stark</name>
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<name sortKey="Whiteman, David" sort="Whiteman, David" uniqKey="Whiteman D" first="David" last="Whiteman">David Whiteman</name>
<name sortKey="Zhen Zhen Zhao" sort="Zhen Zhen Zhao" uniqKey="Zhen Zhen Zhao" last="Zhen Zhen Zhao">ZHEN ZHEN ZHAO</name>
</country>
<country name="Suède"><noRegion><name sortKey="Olsson, Hakan" sort="Olsson, Hakan" uniqKey="Olsson H" first="Hakan" last="Olsson">Hakan Olsson</name>
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<name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name>
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<country name="Italie"><noRegion><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
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</country>
<country name="Pays-Bas"><noRegion><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name>
</noRegion>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Newton Bishop, Julia" sort="Newton Bishop, Julia" uniqKey="Newton Bishop J" first="Julia" last="Newton Bishop">Julia Newton Bishop</name>
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</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Common sequence variants on 20qll.22 confer melanoma susceptibility

Common sequence variants on 20qll.22 confer melanoma susceptibility

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	Serveur d'exploration sur les relations entre la France et l'Australie
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